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The blockade of Aurora kinase B activity using Barasertib attenuates lung fibrosis

The blockade of Aurora kinase B activity using Barasertib attenuates lung fibrosis

By Rajesh K Kasam / September 17, 2020 /

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that develops because of excessive accumulation of ECM components leading to thickening and scarring of the lungs. Aurora kinase B an enzyme involved in various cellular processes was shown to be up regulated and it’s activity can be checked by an inhibitor called Barasertib.

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Functional diversity of SMAX1-Like family

Functional diversity of SMAX1-Like family

By Taraka Ramji Moturu / June 7, 2020 /

This study would aid in unveiling the evolution of strigolactone signalling pathway in the plant development.

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Title Image of Effect of Potassium Ion Channels on Hearing

Effect of Potassium Ion Channels on Hearing

By Nasreen Choudhury / June 7, 2020 /

The article describes Kv3 potassium channel preferences of MNTB and LSO neurons in the auditory brainstem, thus paving the way to understanding auditory deficits in spinocerebral ataxia 13.

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hypertrophic heart

Probing the mRNA 3′-end: A novel path to the gene regulation in heart

By Nimmy Mohan / May 14, 2020 /

A novel anti-hypertrophy gene program was discovered, which is mediated through Star-PAP controlled selective 3’-end processing of cardiac mRNAs along with RBM10.

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title image of RKN parasitism in susceptible and resistant tomato roots

Molecular determinants of RKN parasitism in susceptible and resistant tomato roots using dual RNASeq

By Neha Shukla / April 29, 2020 /

This article is a summary of Transcriptome analysis of root-knot nematode (Meloidogyne incognita)-infected tomato (Solanum lycopersicum) roots reveals complex gene expression profiles and metabolic networks of both host and nematode during susceptible and resistance responses There are a set of definitions at the end of this post to brush up technical terms. Plant-pathogen interactions: A two-way…

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d157mOptn: An isoform of mouse optineurin post featured image

d157mOptn: An isoform of mouse optineurin

By Shivranjani C Moharir / February 7, 2020 /

d157mOptn is a novel isoform of mouse optineurin which is impaired in autophagy, unlike its full length counterpart. It is possible that d157mOptn can regulate the autophagic function of full length optineurin and might have some significance in diseased condition.

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Hero Image. regulation of protein accumulation in Chickpea

Discovery of genes that regulate chickpea seed development and its nutritional quality

By SubodhVerma / January 16, 2020 /

ABI3, a transcription factor, plays a regulatory role in Seed Storage Protein accumulation in developing Chickpea seed. Over-expression of Chickpea ABI3 in Arabidopsis leads to increased protein content without significant changes in seed weight.

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Role of unique inter-motif communication in Ca2+ sensor protein Caldendrin in neuronal signaling

By Uday / January 7, 2020 /

Caldendrin is a neuronal signalling protein shown to be important in learning and memory. In this post, the author of the scientific article explains how CDD sense the calcium by its unique mechanism.

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